The nineteenth and twentieth centuries have witnessed a transformation in the status of scientific authority. With authority comes power, and with power comes the ability to dictate what is inside the realm of value and acceptability and what lies outside of that constructed space. When scientific disciplines and the respected members of those disciplines began to gain cohesion and recognizable authority, they began to make distinctions between what and who was and was not a part of their research programs and acceptable practices. Members of the scientific community especially susceptible to exclusion were (and are) those who had historically been viewed as outsiders — the most studied groups being women and people of color. In this essay, I will examine how this systematic marginalization at various points in science’s ascension to greater and greater political, cultural, and intellectual authority has changed the way that women have practiced science, paying special attention to how the subjects of study and questions asked by female scientists are centered around different issues than their male colleagues. A similar study on African American science would be equally valuable but would extend the breadth of this essay beyond what I can reasonably discuss.