Harriet Deacon, “The Politics of Medical Topography: Seeking healthiness at the Cape during the nineteenth century,” 279-297, in Pathologies of Travel eds. R. Wrigley and G. Revill (Amsterdam: Rodopi, 2000).
Deacon focuses primarily upon the imperial, moral, and economic reasons that Cape Town faded as an important health resort spot in the 19th century. It was longer on an important trade route and was unable to compete with Mediterranean or, more significantly, European health resorts in society and status.
I didn’t find a whole lot useful here, mostly because the focus was not on the role that science played in the Cape’s downfall (and attempts to remain relevant). Deacon spends a lot of time fleshing out the moral implications that the developing city with few aristocratic or other high-ranking imperial officials seemed to have for some of those who commented on it. While its climate was originally held to be quite healthful, the discourse on climate and its deterministic role in the making of the individual increasingly cast doubt onto the location’s healthfulness. Deacon argues that this change was one explained better by imperialistic and economic motives than medical or scientific ones.